We study three estimators for the interval censoring case 2 problem, a
histogram-type estimator, proposed in Birg\'e (1999), the maximum likelihood
estimator (MLE) and the smoothed MLE, using a smoothing kernel. Our focus is on
the asymptotic distribution of the estimators at a fixed point. The estimators
are compared in a simulation study.
We consider the problem of estimating the joint distribution function of the
event time and a continuous mark variable based on censored data. More
specifically, the event time is subject to current status censoring and the
continuous mark is only observed in case inspection takes place after the event
time. The nonparametric maximum likelihood estimator (MLE) in this model is
known to be inconsistent. We propose and study an alternative likelihood based
estimator, maximizing a smoothed log-likelihood, hence called a maximum
smoothed likelihood estimator (MSLE).
We introduce fully nonparametric two sample tests for testing the null
hypothesis that the two samples come from the same distribution if the values
are only indirectly given via current status censoring. The tests are based on
the likelihood ratio principle and allow the observation distributions to be
different for the two samples, in contrast with earlier proposals for this
situation. A bootstrap method is given for determining critical values and
asymptotic theory is developed for one of these tests.
We discuss a number of estimates of the hazard under the assumption that the
hazard is monotone on an interval [0,a]. The usual isotonic least squares
estimators of the hazard are inconsistent at the boundary points 0 and a. We
use penalization to obtain uniformly consistent estimators. Moreover, we
determine the optimal penalization constants, extending related work in this
direction by Woodroofe and Sun (1993) and Woodroofe and Sun (1999). Two methods
of obtaining smooth monotone estimates based on a non-smooth monotone estimator
are discussed.
Two new test statistics are introduced to test the null hypotheses that the
sampling distribution has an increasing hazard rate on a specified interval
[0,a]. These statistics are empirical L_1-type distances between the isotonic
estimates, which use the monotonicity constraint, and either the empirical
distribution function or the empirical cumulative hazard. They measure the
excursions of the empirical estimates with respect to the isotonic estimates,
due to local non-monotonicity.
We introduce a new test statistic for testing the null hypothesis that the
sampling distribution has an increasing hazard rate on a specified interval
[0,a]. It is based on a comparison of the empirical distribution function with
an isotonic estimate, using the restriction that the hazard is increasing, and
measures the excursions of the empirical distribution above the isotonic
estimate, due to local non-monotonicity.
It was shown in Groeneboom (1983) that the least concave majorant of
one-sided Brownian motion without drift can be characterized by a jump process
with independent increments, which is the inverse of the process of slopes of
the least concave majorant. This result can be used to prove the result of
Sparre Andersen (1954) that the number of vertices of the smallest concave
majorant of the empirical distribution function of a sample of size n from the
uniform distribution on [0,1] is asymptotically normal, with an asymptotic
expectation and variance which are both of order log n.
We derive a simple integral representation for the distribution of the
maximum of Brownian motion minus a parabola, which can be used for computing
the density and moments of the distribution, both for one-sided and two-sided
Brownian motion.
In the conviction of Lucia de Berk an important role was played by a simple
hypergeometric model, used by the expert consulted by the court, which produced
very small probabilities of occurrences of certain numbers of incidents. We
want to draw attention to the fact that, if we take into account the variation
among nurses in incidents they experience during their shifts, these
probabilities can become considerably larger. This points to the danger of
using an oversimplified discrete probability model in these circumstances.
We consider the problem of estimating the distribution function, the density
and the hazard rate of the (unobservable) event time in the current status
model. A well studied and natural nonparametric estimator for the distribution
function in this model is the nonparametric maximum likelihood estimator (MLE).
We study two alternative methods for the estimation of the distribution
function, assuming some smoothness of the event time distribution. The first
estimator is based on a maximum smoothed likelihood approach.