We consider the problems of estimation and selection of parameters endowed
with a known group structure, when the groups are assumed to be sign-coherent,
that is, gathering either non-negative, non-positive or null parameters. To
tackle this problem we propose a new penalty that we call the cooperative-Lasso
penalty. We derive the optimality conditions defining the cooperative-Lasso
estimate for generalized linear models and propose an efficient active set
algorithm suited to high-dimensional problems.
Gaussian Graphical Models provide a convenient framework for representing
dependencies between variables. Recently, this tool has received a high
interest for the discovery of biological networks. The litterature focuses on
the case where a single network is inferred from a set of measurements, but, as
wetlab data is typically scarce, several assays, where the experimental
conditions affect interactions, are usually merged to infer a single network.