We consider the problem of estimating the division rate of a size-structured
population in a nonparametric setting. The size of the system evolves according
to a transport-fragmentation equation: each individual grows with a given
transport rate, and splits into two offsprings of the same size, following a
binary fragmentation process with unknown division rate that depends on its
size.
We analyze the asymptotic behavior of a partial differential equation (PDE)
model for hematopoiesis. This PDE model is derived from the original
agent-based model formulated by (Roeder et al., Nat. Med., 2006), and it
describes the progression of blood cell development from the stem cell to the
terminally differentiated state. To conduct our analysis, we start with the PDE
model of (Kim et al, JTB, 2007), which coincides very well with the simulation
results obtained by Roeder et al.
The aim of this work is twofold. First, we survey the techniques developed in
(Perthame, Zubelli, 2007) and (Doumic, Perthame, Zubelli, 2008) to reconstruct
the division (birth) rate from the cell volume distribution data in certain
structured population models. Secondly, we implement such techniques on
experimental cell volume distributions available in the literature so as to
validate the theoretical and numerical results.
The aim of this work is twofold. First, we survey the techniques developed in
(Perthame, Zubelli, 2007) and (Doumic, Perthame, Zubelli, 2008) to reconstruct
the division (birth) rate from the cell volume distribution data in certain
structured population models. Secondly, we implement such techniques on
experimental cell volume distributions available in the literature so as to
validate the theoretical and numerical results.