Single-particle electron microscopy is a modern technique that biophysicists
employ to learn the structure of proteins. It yields data that consist of noisy
random projections of the protein structure in random directions, with the
added complication that the projection angles cannot be observed. In order to
reconstruct a three-dimensional model, the projection directions need to be
estimated by use of an ad-hoc starting estimate of the unknown particle.
David Ross Brillinger was born on the 27th of October 1937, in Toronto,
Canada. In 1955, he entered the University of Toronto, graduating with a B.A.
with Honours in Pure Mathematics in 1959, while also serving as a Lieutenant in
the Royal Canadian Naval Reserve. He was one of the five winners of the Putnam
mathematical competition in 1958. He then went on to obtain his M.A. and Ph.D.
in Mathematics at Princeton University, in 1960 and 1961, the latter under the
guidance of John W. Tukey.
We formulate and investigate a statistical inverse problem of a random
tomographic nature, where a probability density function on $\mathbb{R}^3$ is
to be recovered from observation of finitely many of its two-dimensional
projections in random and unobservable directions. Such a problem is distinct
from the classic problem of tomography where both the projections and the unit
vectors normal to the projection plane are observable. The problem arises in
single particle electron microscopy, a powerful method that biophysicists
employ to learn the structure of biological macromolecules.