Paul Joyce

  1. Maximum likelihood estimates under $\mathbf{k}$-allele models with selection can be numerically unstable.

    Authors: Erkan Ozge Buzbas, Paul Joyce
    Subjects: Applications
    Abstract

    The stationary distribution of allele frequencies under a variety of
    Wright--Fisher $k$-allele models with selection and parent independent mutation
    is well studied. However, the statistical properties of maximum likelihood
    estimates of parameters under these models are not well understood. Under each
    of these models there is a point in data space which carries the strongest
    possible signal for selection, yet, at this point, the likelihood is unbounded.
    This result remains valid even if all of the mutation parameters are assumed to
    be known.

  2. Maximum likelihood estimates under $\mathbf{k}$-allele models with selection can be numerically unstable.

    Authors: Erkan Ozge Buzbas, Paul Joyce
    Subjects: Applications
    Abstract

    The stationary distribution of allele frequencies under a variety of
    Wright--Fisher $k$-allele models with selection and parent independent mutation
    is well studied. However, the statistical properties of maximum likelihood
    estimates of parameters under these models are not well understood. Under each
    of these models there is a point in data space which carries the strongest
    possible signal for selection, yet, at this point, the likelihood is unbounded.
    This result remains valid even if all of the mutation parameters are assumed to
    be known.

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