The efficient repair of cellular DNA is essential for the maintenance and
inheritance of genomic information. In order to cope with the high frequency of
spontaneous and induced DNA damage, a multitude of repair mechanisms have
evolved. These are enabled by a wide range of protein factors specifically
recognizing different types of lesions and finally restoring the normal DNA
sequence. This work focuses on the repair factor XPC (xeroderma pigmentosum
complementation group C), which identifies bulky DNA lesions and initiates
their removal via the nucleotide excision repair pathway.