We present a technique to characterize differentially expressed genes in
terms of their position in a high-dimensional co-expression network. The set-up
of Gaussian graphical models is used to construct representations of the
co-expression network in such a way that redundancy and the propagation of
spurious information along the network are avoided. The proposed inference
procedure is based on the minimization of the Bayesian Information Criterion
(BIC) in the class of decomposable graphical models.
This paper presents the R package gRapHD for efficient selection of
high-dimensional undirected graphical models. The package provides tools for
selecting trees, forests and decomposable models minimizing information
criteria such as AIC or BIC, and for displaying the independence graphs of the
models. It has also some useful tools for analysing graphical structures. It
supports the use of discrete, continuous, or both types of variables.