Nancy Geller

  1. Robust Tests in Genome-Wide Scans under Incomplete Linkage Disequilibrium.

    Authors: Gang Zheng, Jungnam Joo, Dmitri Zaykin, Colin Wu, Nancy Geller
    Subjects: Methodology
    Abstract

    Under complete linkage disequilibrium (LD), robust tests often have greater
    power than Pearson's chi-square test and trend tests for the analysis of
    case-control genetic association studies. Robust statistics have been used in
    candidate-gene and genome-wide association studies (GWAS) when the genetic
    model is unknown. We consider here a more general incomplete LD model, and
    examine the impact of penetrances at the marker locus when the genetic models
    are defined at the disease locus.

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