Jorge P. Zubelli

  1. A Structured Population Model of Cell Differentiation.

    Authors: Jorge P. Zubelli, Marie Doumic, Anna Marciniak-Czochra, Benoit Perthame
    Subjects: Analysis of PDEs
    Abstract

    We introduce and analyze several aspects of a new model for cell
    differentiation. It assumes that differentiation of progenitor cells is a
    continuous process. From the mathematical point of view, it is based on partial
    differential equations of transport type. Specifically, it consists of a
    structured population equation with a nonlinear feedback loop. This models the
    signaling process due to cytokines, which regulate the differentiation and
    proliferation process.

  2. On the Calibration of a Size-Structured Population Model from Experimental Data.

    Authors: Marie Doumic Jauffret, Pedro Maia, Jorge P. Zubelli
    Subjects: Numerical Analysis
    Abstract

    The aim of this work is twofold. First, we survey the techniques developed in
    (Perthame, Zubelli, 2007) and (Doumic, Perthame, Zubelli, 2008) to reconstruct
    the division (birth) rate from the cell volume distribution data in certain
    structured population models. Secondly, we implement such techniques on
    experimental cell volume distributions available in the literature so as to
    validate the theoretical and numerical results.

  3. On the Calibration of a Size-Structured Population Model from Experimental Data.

    Authors: Marie Doumic Jauffret, Pedro Maia, Jorge P. Zubelli
    Subjects: Numerical Analysis
    Abstract

    The aim of this work is twofold. First, we survey the techniques developed in
    (Perthame, Zubelli, 2007) and (Doumic, Perthame, Zubelli, 2008) to reconstruct
    the division (birth) rate from the cell volume distribution data in certain
    structured population models. Secondly, we implement such techniques on
    experimental cell volume distributions available in the literature so as to
    validate the theoretical and numerical results.

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