Hiroaki Uehara

  1. Pooling Design and Bias Correction in DNA Library Screening.

    Authors: Takafumi Kanamori, Hiroaki Uehara, Masakazu Jimbo
    Subjects: Computation
    Abstract

    We study the group test for DNA library screening based on probabilistic
    approach. Group test is a method of detecting a few positive items from among a
    large number of items, and has wide range of applications. In DNA library
    screening, positive item corresponds to the clone having a specified DNA
    segment, and it is necessary to identify and isolate the positive clones for
    compiling the libraries. In the group test, a group of items, called pool, is
    assayed in a lump in order to save the cost of testing, and positive items are
    detected based on the observation from each pool.

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