Li Hsu

  1. Bootstrap Inference for Network Construction.

    Authors: Pei Wang, Li Hsu, Jie Peng, Shuang Li
    Subjects: Methodology
    Abstract

    Regularization techniques are widely used for tackling
    high-dimension-low-sample-size problems. Yet, finding the right amount of
    regularization can be challenging, especially in the unsupervised setting such
    as structure learning problems where traditional methods such as BIC or
    cross-validation often do not work well. In this paper, we propose a new method
    --- Bootstrap Inference for Network COnstruction (BINCO) --- to infer networks
    by directly controlling the false discovery rates (FDRs) of the selected edges.
    This method utilizes the idea of model aggregation.

  2. Learning networks from high dimensional binary data: An application to genomic instability data.

    Authors: Pei Wang, Dennis L. Chao, Li Hsu
    Subjects: Methodology
    Abstract

    Genomic instability, the propensity of aberrations in chromosomes, plays a
    critical role in the development of many diseases. High throughput genotyping
    experiments have been performed to study genomic instability in diseases. The
    output of such experiments can be summarized as high dimensional binary
    vectors, where each binary variable records aberration status at one marker
    locus. It is of keen interest to understand how these aberrations interact with
    each other. In this paper, we propose a novel method, \texttt{LogitNet}, to
    infer the interactions among aberration events.

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