Dennis L. Chao

  1. Learning networks from high dimensional binary data: An application to genomic instability data.

    Authors: Pei Wang, Dennis L. Chao, Li Hsu
    Subjects: Methodology
    Abstract

    Genomic instability, the propensity of aberrations in chromosomes, plays a
    critical role in the development of many diseases. High throughput genotyping
    experiments have been performed to study genomic instability in diseases. The
    output of such experiments can be summarized as high dimensional binary
    vectors, where each binary variable records aberration status at one marker
    locus. It is of keen interest to understand how these aberrations interact with
    each other. In this paper, we propose a novel method, \texttt{LogitNet}, to
    infer the interactions among aberration events.

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