A dynamic treatment regime effectively incorporates both accrued information
and long-term effects of treatment from specially designed clinical trials. As
these become more and more popular in conjunction with longitudinal data from
clinical studies, the development of statistical inference for optimal dynamic
treatment regimes is a high priority.
A variable screening procedure via correlation learning was proposed Fan and
Lv (2008) to reduce dimensionality in sparse ultra-high dimensional models.
Even when the true model is linear, the marginal regression can be highly
nonlinear. To address this issue, we further extend the correlation learning to
marginal nonparametric learning. Our nonparametric independence screening is
called NIS, a specific member of the sure independence screening. Several
closely related variable screening procedures are proposed.
Ultrahigh dimensional variable selection plays an increasingly important role
in contemporary scientific discoveries and statistical research. Among others,
Fan and Lv (2008) propose an independent screening framework by ranking the
marginal correlations. They showed that the correlation ranking procedure
possesses a sure independence screening property within the context of the
linear model with Gaussian covariates and responses.
Ultrahigh dimensional variable selection plays an increasingly important role
in contemporary scientific discoveries and statistical research. Among others,
Fan and Lv (2008) propose an independent screening framework by ranking the
marginal correlations. They showed that the correlation ranking procedure
possesses a sure independence screening property within the context of the
linear model with Gaussian covariates and responses.
We consider tests of hypotheses when the parameters are not identifiable
under the null in semiparametric models, where regularity conditions for
profile likelihood theory fail. Exponential average tests based on integrated
profile likelihood are constructed and shown to be asymptotically optimal under
a weighted average power criterion with respect to a prior on the
nonidentifiable aspect of the model. These results extend existing results for
parametric models, which involve more restrictive assumptions on the form of
the alternative than do our results.