We address the question of when cluster-tilted algebras of Dynkin type E are
derived equivalent and as main result obtain a complete derived equivalence
classification. It turns out that two cluster-tilted algebras of type E are
derived equivalent if and only if their Cartan matrices represent equivalent
bilinear forms over the integers which in turn happens if and only if the two
algebras are connected by a sequence of "good" mutations. For type E6 all
details are given in the paper, for types E7 and E8 we present the results in a
concise form from which our findings should easily be verifiable.